Kagoura M, Toyoda M, Nagahori H, Makino T, Morohashi M
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama 930-0194, Japan.
Eur J Dermatol. 1999 Jul-Aug;9(5):366-9.
A case of Bednar tumor on the right shoulder of a 47-year-old Japanese woman is reported. Histological examination showed plump, spindle cells arranged in a storiform pattern in central areas of the tumor and a diffuse infiltration of the dermal stroma, which was frequently extended into the subcutis at the periphery of the tumor. The tumor contained a fairly identified population of dendritic pigmented cells. Ultrastructurally, most cells had folded nuclei, were spindle-shaped and had long, slender cytoplasmic projections. Dendritic pigmented cells, which were dispersed among neoplastic cells, contained premelanosomes and mature melanosomes. Immunohistochemically, tumor cells exhibited positive reactions for vimentin and CD 34 and failed to show a positive reaction for neuron specific enolase, HMB-45 or S-100 protein. Factor X IIIa was only expressed on tumor cells around melanin-containing cells, which reacted positively with antibodies to S-100 protein and vimentin. These results indicate that the phenotype of tumor cells around melanin-containing cells differs from other tumor cells and that this difference may be caused by the relationship of tumor cells and melanin-containing cells.
报告了一例47岁日本女性右肩部的贝德纳瘤病例。组织学检查显示，肿瘤中央区域的丰满梭形细胞呈漩涡状排列，真皮基质弥漫性浸润，常延伸至肿瘤周边的皮下组织。肿瘤含有相当数量的树突状色素细胞。超微结构上，大多数细胞有折叠的细胞核，呈梭形，有长而细的细胞质突起。分散在肿瘤细胞中的树突状色素细胞含有前黑素体和成熟黑素体。免疫组织化学检查显示，肿瘤细胞波形蛋白和CD 34呈阳性反应，神经元特异性烯醇化酶、HMB - 45或S - 100蛋白呈阴性反应。因子X IIIa仅在含黑色素细胞周围的肿瘤细胞上表达，这些细胞与抗S - 100蛋白和波形蛋白的抗体呈阳性反应。这些结果表明，含黑色素细胞周围的肿瘤细胞表型与其他肿瘤细胞不同，这种差异可能是由肿瘤细胞与含黑色素细胞的关系引起的。
