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动脉栓塞术治疗创伤后阴茎异常勃起

Arterial embolization in the treatment of post-traumatic priapism.

作者信息

Colombo F, Lovaria A, Saccheri S, Pozzoni F, Montanaris E

机构信息

Institute of Urology, Ospedale Maggiore I.R.C.C.S., Milano, Italy.

出版信息

Ann Urol (Paris). 1999;33(3):210-8.

Abstract

Priapism is a prolonged penile erection not associated with sexual arousal. Two types of priapism have been described: the more common one is the "veno-occlusive" priapism and can be frequently observed as the consequence of an intracavernosal injection of vaso-active drugs for the treatment of erectile dysfunction. The less common type of priapism is known as "high flow" priapism and usually follows perineal or direct penile trauma. The clinical presentation in case of high flow priapism is quite typical: hystory of recent penile or perineal trauma followed, by the onset of a painless, incomplete and constant erection of the penis. A color-flow Doppler sonogram should be performed as first diagnostic step: this examination allows to identify the presence of patent cavernous arteries and prominent venous drainage with focal area of high flow turbulence along the pathway of one or both the cavernous arteries. An arterial blood sample taken from the corpora will confirm the diagnosis. At first, conservative therapeutical attempts can be suggested, with mechanical external compression of the perineum, the use of ice packs, corporeal aspiration and irrigation with saline. Besides, intracorporeal administration of alpha-agonists and methylene blue should be performed. Unfortunately, these conservative measures often result unsuccessful, and more invasive approaches must be considered. The radiological superselective transcatheter embolization of the proximal artery supplying arterial-lacunar fistula should be the present treatment of choice in these cases of high-flow priapism refractory to conservative and medical treatments. The first successful management of high flow priapism by selective arterial embolization was reported by Wear and coworkers in 1977. Autologous clots and gelatine sponge have been extensively used and become very popular as the embolic agent. More recently, platinum microcoils have been proposed with the aim to achieve more precise and selective embolization. In our single-case-experience on the treatment of high flow priapism by arterial embolization, we used the recently introduced tungsten microcoils. At the time of the follow-up, 2 months later, patient reported satisfactory intercourse with an approximately 75% of penile rigidity. By comparison with microsurgical ligature of the damaged vessel, selective embolization is, at least theoretically, a less invasive procedure, particularly with reference to the trauma caused to the erectile tissue. High-flow priapism is a fairly rare urological pathology which does not require immediate and emergency treatment (as is the case, instead, with venous-occlusive priapism), since the risk of post-ischaemic fibrosis is excluded thanks to the fact that oxygen is supplied to the cavernous tissue. Once the diagnosis has been established with certainty, therefore, the specialist has the necessary time at disposal to arrange for the most appropriate therapeutic steps. When, as is frequently the case, conservative measures prove ineffective, the current treatment of choice for cases of fistula of the cavernous artery would appear to be superselective embolization of the artery, provided same can be performed at specialized centres and by experienced personnel.

摘要

阴茎异常勃起是一种与性唤起无关的持续性阴茎勃起。阴茎异常勃起可分为两种类型:较常见的是“静脉闭塞性”阴茎异常勃起,常因海绵体内注射血管活性药物治疗勃起功能障碍所致。较不常见的类型是“高流量性”阴茎异常勃起,通常继发于会阴部或阴茎直接创伤。高流量性阴茎异常勃起的临床表现颇为典型:近期有阴茎或会阴部创伤史,随后出现无痛、不完全且持续的阴茎勃起。首先应进行彩色多普勒超声检查作为诊断步骤:该检查可确定海绵体动脉通畅以及静脉引流显著,沿一条或两条海绵体动脉走行有局灶性高流量湍流区域。从阴茎海绵体采集动脉血样本可确诊。起初,可尝试保守治疗,包括会阴部机械性外部压迫、使用冰袋、阴茎海绵体抽吸及生理盐水冲洗。此外,应进行阴茎海绵体内注射α - 激动剂和亚甲蓝。不幸的是,这些保守措施往往不成功,必须考虑更具侵入性的方法。对于保守治疗和药物治疗无效的高流量性阴茎异常勃起病例,目前的治疗选择应为对供应动脉 - 海绵体瘘的近端动脉进行放射学超选择性经导管栓塞。1977年,Wear及其同事报道了首例通过选择性动脉栓塞成功治疗高流量性阴茎异常勃起的病例。自体血凝块和明胶海绵已被广泛用作栓塞剂且非常受欢迎。最近,有人提出使用铂微线圈以实现更精确和选择性的栓塞。在我们通过动脉栓塞治疗高流量性阴茎异常勃起的单病例经验中,我们使用了最近引入的钨微线圈。在2个月后的随访中,患者报告性交满意度良好,阴茎硬度约为75%。与受损血管的显微外科结扎相比,选择性栓塞至少在理论上是一种侵入性较小的手术,尤其是对勃起组织造成的创伤方面。高流量性阴茎异常勃起是一种相当罕见的泌尿外科疾病,不需要立即进行紧急治疗(静脉闭塞性阴茎异常勃起则相反),因为海绵体组织有氧气供应,可排除缺血后纤维化的风险。因此,一旦确诊,专科医生有足够的时间安排最合适的治疗步骤。当保守措施通常无效时,对于海绵体动脉瘘病例,目前的治疗选择似乎是对动脉进行超选择性栓塞,前提是在专业中心由经验丰富的人员进行操作。

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