Likar R, Spendel M C, Amberger W, Kepplinger B, Supanz S, Sadjak A
Department of Anaesthesiology and Intensive Care, General Hospital Klagenfurt, Austria.
Arzneimittelforschung. 1999 Jun;49(6):489-93. doi: 10.1055/s-0031-1300448.
Experiences with long-term intraspinal infusion of opioid drugs using the new implantable medication pump VIP 30 in patients with chronic non-malignant pain are reported. During a 19-month period 10 patients with chronic pain--mainly mixed nociceptive-neuropathic pain--underwent implantation of the medication pump for long-term treatment. The mean follow-up period was 9.5 months. Pain relief was classified as very good in 22.2%, good in 44.4%, moderate in 22.2% and poor in 11.1%. In 88.9% of the cases the patients stated they would undergo the same procedure again. Technical problems (catheter dislocation) developed in 1/10 patients could be surgically corrected. One pump including catheter was explanted because of an infected seroma within the pocket area. Long-term intrathecal application of opioids with the VIP 30 pumps is an effective and safe treatment in patients with chronic non-malignant pain.
报告了使用新型植入式药物泵VIP 30对慢性非恶性疼痛患者进行长期脊髓内输注阿片类药物的经验。在19个月期间，10例慢性疼痛患者（主要为混合性伤害感受性-神经性疼痛）接受了药物泵植入以进行长期治疗。平均随访期为9.5个月。疼痛缓解程度分类为：非常好占22.2%，好占44.4%，中等占22.2%，差占11.1%。88.9%的患者表示愿意再次接受相同的治疗。1/10的患者出现技术问题（导管移位），可通过手术纠正。因囊袋区域出现感染性血清肿，取出了1个包括导管的泵。使用VIP 30泵进行长期鞘内应用阿片类药物对慢性非恶性疼痛患者是一种有效且安全的治疗方法。
