Honderlick P, Saheb F, Cahen P
Microbiologie, Hôpital Foch, Suresnes, France.
Pathol Biol (Paris). 1999 May;47(5):437-9.
Frequent selection of mutants resistant to extended and broad spectrum cephalosporins in Enterobacter cloacae is observed in hospital. As we noticed an unusual number of isolates of these strains and to answer the question arose whether these Enterobacter had a common source, we retrospectivally studied 56 strains collected in 11 wards of the hospital. Using PFGE with Spe 1 restriction analysis we identified a prevalent clone (11 patients) dispatched in 8 wards. We also obviously proved cross-contamination patients to patients with other clones. PFGE allow us to point out that clonal Enterobacter cloacae has taken place in our hospital, even if there is no real outbreak. A reinforcement of basic hygienic measures and a control of antibiotics prescription seemed very important to jugulate the sudden increase of multiresistant Enterobacter cloacae prevalence.
在医院中观察到阴沟肠杆菌频繁出现对超广谱头孢菌素耐药的突变体。由于我们注意到这些菌株的分离株数量异常，并且为了回答这些阴沟肠杆菌是否有共同来源的问题，我们回顾性研究了从医院11个病房收集的56株菌株。使用Spe 1限制性分析的脉冲场凝胶电泳（PFGE），我们鉴定出一个在8个病房分布的流行克隆（涉及11名患者）。我们还明显证明了患者之间存在与其他克隆的交叉污染。PFGE使我们能够指出，即使没有真正的暴发，我院也发生了阴沟肠杆菌的克隆传播。加强基本卫生措施和控制抗生素处方对于遏制多重耐药阴沟肠杆菌患病率的突然上升似乎非常重要。
