Belchetz P, Dufy B, Knobil E
Neuroendocrinology. 1978;27(1-2):32-8. doi: 10.1159/000122798.
In the unanesthetized, ovariectomized rhesus monkey, gonadotropin secretion is episodic while prolactin (Prl) release is relatively constant. Under pentobarbital anesthesia, however, Prl secretion also becomes pulsatile in synchrony with the discharges of LH. This finding suggests that the anesthesia has unmasked normally inhibited Prl releasing stimuli which are driven by the circhoral 'clock' that also times the discharges of GnRH.
在未麻醉的去卵巢恒河猴中，促性腺激素分泌是间歇性的，而催乳素（Prl）释放相对恒定。然而，在戊巴比妥麻醉下，Prl分泌也会与促黄体生成素（LH）的释放同步出现脉冲式变化。这一发现表明，麻醉解除了通常对Prl释放刺激的抑制，这些刺激由昼夜节律“时钟”驱动，该时钟也为促性腺激素释放激素（GnRH）的释放定时。
