新型选择性Δ6或Δ5脂肪酸去饱和酶抑制剂作为小鼠体内的抗炎剂 - Suppr

Suppr

超能文献

Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.

作者信息

Obukowicz M, Welsch D, Salsgiver W, Martin-Berger C, Chinn K, Duffin K, Raz A, Needleman P

机构信息

G.D. Searle, Discovery Pharmacology, St. Louis, Missouri 63198, USA.

出版信息

Lipids. 1999;34 Suppl:S149. doi: 10.1007/BF02562269.

DOI:10.1007/BF02562269

PMID:10419129

Abstract

摘要

相似文献

Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.新型选择性Δ6或Δ5脂肪酸去饱和酶抑制剂作为小鼠体内的抗炎剂

Lipids. 1999;34 Suppl:S149. doi: 10.1007/BF02562269.

Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent.一种新型Δ6/Δ5脂肪酸去饱和酶抑制剂作为潜在抗炎剂的鉴定与表征

Biochem Pharmacol. 1998 Apr 1;55(7):1045-58. doi: 10.1016/s0006-2952(97)00665-5.

Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice.新型选择性Δ6或Δ5脂肪酸去饱和酶抑制剂作为小鼠体内的抗炎剂

J Pharmacol Exp Ther. 1998 Oct;287(1):157-66.

Lipid remodeling in mouse liver and plasma resulting from delta6 fatty acid desaturase inhibition.由Δ6脂肪酸去饱和酶抑制导致的小鼠肝脏和血浆中的脂质重塑。

Lipids. 2001 Nov;36(11):1203-8. doi: 10.1007/s11745-001-0833-2.

Highly unsaturated fatty acid synthesis in vertebrates: new insights with the cloning and characterization of a delta6 desaturase of Atlantic salmon.脊椎动物中高度不饱和脂肪酸的合成：大西洋鲑δ6去饱和酶的克隆与表征带来的新见解

Lipids. 2005 Jan;40(1):13-24. doi: 10.1007/s11745-005-1355-7.

Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations.Δ6-、硬脂酰辅酶A-和Δ5-去饱和酶在β细胞中表达，并会因外源性多不饱和脂肪酸浓度的增加而发生改变。

Biochim Biophys Acta. 2002 Jan 30;1580(1):40-56. doi: 10.1016/s1388-1981(01)00189-5.

Differential effect of N-ethyl maleimide on delta6-desaturase activity in human fetal liver toward fatty acids of the n-6 and n-3 series.N-乙基马来酰亚胺对人胎儿肝脏中δ6-去饱和酶针对n-6和n-3系列脂肪酸活性的差异作用。

Lipids. 1999 Jan;34(1):23-30. doi: 10.1007/s11745-999-333-4.

Fatty acid desaturase activities and polyunsaturated fatty acid composition in human liver between the seventeenth and thirty-sixth gestational weeks.孕17至36周期间人肝脏中的脂肪酸去饱和酶活性及多不饱和脂肪酸组成

Am J Obstet Gynecol. 1998 Oct;179(4):1063-70. doi: 10.1016/s0002-9378(98)70216-9.

A fatty acyl desaturase (fads2) with dual Δ6 and Δ5 activities from the freshwater carnivorous striped snakehead Channa striata.来自淡水肉食性条纹鳢鱼（Channa striata）的具有Δ6和Δ5双重活性的脂肪酰基去饱和酶（fads2）。

Comp Biochem Physiol A Mol Integr Physiol. 2016 Nov;201:146-155. doi: 10.1016/j.cbpa.2016.07.007. Epub 2016 Jul 12.

Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.

Cancer Lett. 2002 Jan 25;175(2):157-63. doi: 10.1016/s0304-3835(01)00715-7.

引用本文的文献

The Association Between Plasma Fatty Acid and Cognitive Function Mediated by Inflammation in Patients with Type 2 Diabetes Mellitus.2型糖尿病患者血浆脂肪酸与认知功能之间的关联：炎症介导作用

Diabetes Metab Syndr Obes. 2022 May 6;15:1423-1436. doi: 10.2147/DMSO.S353449. eCollection 2022.

De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for .从头合成的多不饱和脂肪酸既作为宿主免疫调节剂，也作为的营养物质发挥作用。

Elife. 2021 Dec 24;10:e71946. doi: 10.7554/eLife.71946.

Risk of secondary lymphedema in breast cancer survivors is related to serum phospholipid fatty acid desaturation.乳腺癌幸存者发生继发性淋巴水肿的风险与血清磷脂脂肪酸去饱和作用有关。

Support Care Cancer. 2016 Sep;24(9):3767-74. doi: 10.1007/s00520-016-3197-z. Epub 2016 Apr 4.

Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals.培养的代谢健康与不健康肥胖个体脂肪细胞的代谢特征。

PLoS One. 2014 Apr 2;9(4):e93148. doi: 10.1371/journal.pone.0093148. eCollection 2014.

Delta-6-desaturase activity and arachidonic acid synthesis are increased in human breast cancer tissue.人乳腺癌组织中 δ-6 去饱和酶活性和花生四烯酸合成增加。

Cancer Sci. 2013 Jun;104(6):760-4. doi: 10.1111/cas.12129. Epub 2013 Mar 19.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验