妊娠合并免疫性血小板减少性紫癜时新生儿血小板减少的风险较低。
Low neonatal risk of thrombocytopenia in pregnancy associated with immune thrombocytopenic purpura.
作者信息
Song T B, Lee J Y, Kim Y H, Choi Y Y
机构信息
Department of Obstetrics and Gynecology, Chonnam University Medical School, Kwangju, Korea.
出版信息
Fetal Diagn Ther. 1999 Jul-Aug;14(4):216-9. doi: 10.1159/000020924.
OBJECTIVE
To estimate the risk of neonatal thrombocytopenia in infants born to mothers with immune thrombocytopenic purpura (ITP).
METHODS
During the years 1993-1997, there were 6,082 deliveries. There were 32 infants born to 31 mothers with ITP. Cordocentesis was performed between 34 and 41 weeks of gestation in 16 mothers with ITP. The cord blood platelet count was checked in all cases at delivery.
RESULTS
In mothers with ITP, 5 neonates (15.6%) had mild thrombocytopenia and 7 neonates (21.9%) moderate thrombocytopenia. Severe thrombocytopenia was not observed in any neonate born to mothers with ITP.
CONCLUSIONS
The means of delivery in pregnant women with ITP can be determined solely on the basis of obstetric indications because the incidence of severe fetal and neonatal thrombocytopenia is very rare, neonatal intracranial hemorrhage is unlikely to be related to the mode of delivery and percutaneous umbilical blood sampling is technically difficult with a risk of fetal death.
目的
评估患有免疫性血小板减少性紫癜（ITP）的母亲所生婴儿发生新生儿血小板减少症的风险。
方法
在1993年至1997年期间，共有6082例分娩。31例患有ITP的母亲生下了32名婴儿。对16例患有ITP的母亲在妊娠34至41周期间进行了脐血穿刺。所有病例在分娩时均检查了脐血血小板计数。
结果
患有ITP的母亲所生的新生儿中，5例（15.6%）有轻度血小板减少症，7例（21.9%）有中度血小板减少症。患有ITP的母亲所生的任何新生儿均未观察到严重血小板减少症。
结论
ITP孕妇的分娩方式可仅根据产科指征确定，因为严重胎儿和新生儿血小板减少症的发生率非常低，新生儿颅内出血不太可能与分娩方式有关，且经皮脐血采样技术难度大，有胎儿死亡风险。
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