Roszkowska A M, Tringali C G, Colosi P, Squeri C A, Ferreri G
Institute of Ophthalmology, University of Messina, Italy.
Ophthalmologica. 1999;213(4):258-61. doi: 10.1159/000027431.
The purpose of this study is to evaluate the corneal endothelium in type I and type II diabetic patients.
Seventy-five diabetics divided into type I and type II groups and 62 healthy volunteers took part in the study. The mean endothelial cell density and morphology, and the central corneal thickness were evaluated and statistical analysis was done.
All evaluated parameters were found to be significantly different in both diabetic groups with reduction of the mean cell density of 5% in type II and of 11% in type I diabetes with respect to the normal age-matched control group. Important alterations of endothelial morphology were observed. The central corneal pachymetry was significantly higher in diabetics, with p < 0.01 in the type I group and p < 0.05 in the type II group.
It is concluded that corneal endothelium in diabetics should still be considered as a tissue under continuous metabolic stress with consequent high vulnerability, especially in case of any external insult such as a surgical procedure.
本研究的目的是评估I型和II型糖尿病患者的角膜内皮。
75名糖尿病患者分为I型和II型组，62名健康志愿者参与了本研究。评估了平均内皮细胞密度和形态以及中央角膜厚度，并进行了统计分析。
发现两个糖尿病组中所有评估参数均存在显著差异，与年龄匹配的正常对照组相比，II型糖尿病患者平均细胞密度降低5%，I型糖尿病患者降低11%。观察到内皮形态有重要改变。糖尿病患者的中央角膜测厚明显更高，I型组p<0.01，II型组p<0.05。
得出结论，糖尿病患者的角膜内皮仍应被视为处于持续代谢应激下的组织，因此易损性高，尤其是在遭受任何外部损伤如外科手术时。
