糖尿病视网膜病变与角膜内皮参数：一项分析性横断面研究。
Diabetic retinopathy and corneal endothelial parameters: an analytical cross-sectional study.
机构信息
Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
BMC Ophthalmol. 2022 Nov 9;22(1):427. doi: 10.1186/s12886-022-02667-6.
BACKGROUND
To investigate the possible association of different pattern of diabetic retinopathy (DR) on corneal endothelium cells in type 2 diabetes mellitus patients.
METHODS
In this descriptive-analytical cross-sectional study, corneal endothelium parameters including endothelial cell density (ECD), average cell size (AVG), coefficient of variation in cell size (CV), and hexagonality (Hex) were evaluated by non-contact specular microscopy.
RESULTS
One hundred and thirty-four eyes of 134 diabetic patients including 77 females (57.5%) with a mean age of 61.03 ± 8.08 years were enrolled. The overall corneal parameters in diabetic patients with and without retinopathy were not significantly different (P > 0.05). There is a significant relationship between CV and the duration of the disease with age variable control (B = 0.369, p-value < 0.001).
CONCLUSIONS
Corneal endothelial parameters were not associated with DM in patients without and with DR. There is a significant relationship between CV and the duration of the disease with age variable control.
背景
探讨 2 型糖尿病患者不同类型糖尿病视网膜病变（DR）与角膜内皮细胞的可能相关性。
方法
本研究采用描述性分析性横断面研究，通过非接触式共焦显微镜评估角膜内皮细胞参数，包括内皮细胞密度（ECD）、平均细胞大小（AVG）、细胞大小变异系数（CV）和六边形细胞比例（Hex）。
结果
共纳入 134 例糖尿病患者的 134 只眼，其中女性 77 例（57.5%），平均年龄为 61.03±8.08 岁。有和无视网膜病变的糖尿病患者的整体角膜参数无显著差异（P>0.05）。在控制年龄变量后，CV 与疾病持续时间之间存在显著关系（B=0.369，p 值<0.001）。
结论
在无和有 DR 的 DM 患者中，角膜内皮参数与 DM 无关。在控制年龄变量后，CV 与疾病持续时间之间存在显著关系。
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