糖尿病大鼠晶状体中的超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和黄嘌呤氧化酶。
Superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase in diabetic rat lenses.
作者信息
Cekiç O, Bardak Y, Totan Y, Akyol O, Zilelioglu G
机构信息
Department of Ophthalmology, Ankara University School of Medicine, Ankara, Turkey.
出版信息
Ophthalmic Res. 1999;31(5):346-50. doi: 10.1159/000055557.
The activities of the protective enzymes, superoxide dismutase, catalase, glutathione peroxidase and of xanthine oxidase, an enzyme acting as a source of O(-)(2), were measured in the lenses of alloxan-induced diabetic and control rats. Superoxide dismutase and glutathione peroxidase activities were found to be significantly decreased, while catalase and xanthine oxidase activities were increased. This means that the ratio of the oxidant/antioxidant enzymes increases in the diabetic rat lens, suggesting an increased oxidative stress. This imbalance is possibly an important contributing factor in the pathogenesis of diabetic cataract.
在四氧嘧啶诱导的糖尿病大鼠和对照大鼠的晶状体中，测定了保护性酶超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶以及作为O(-)(2)来源的黄嘌呤氧化酶的活性。发现超氧化物歧化酶和谷胱甘肽过氧化物酶的活性显著降低，而过氧化氢酶和黄嘌呤氧化酶的活性增加。这意味着糖尿病大鼠晶状体中氧化酶/抗氧化酶的比例增加，表明氧化应激增加。这种失衡可能是糖尿病性白内障发病机制中的一个重要促成因素。
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