Moskowitz L
Heart Lung. 1975 Nov-Dec;4(6):939-45.
In the context of these studies, the evidence indicates that cardiac performance can improve significantly during vasodilator therapy in acute MI complicated by pump failure. Although the clinical course in uncomplicated patients is good, even without active therapeutic interventions, prognosis in patients with pump failure treated by standard methods (digitalis and diutetics) is discouraging. Hospital mortality approaches "40 per cent in patients with moderately depressed cardiac function and may reach as high as 100 per cent in patients with severe pump failure and/or cardiogenic shock." The evidence presented suggests that early and cautious vasodilator therapy may significantly alter this poor prognosis by its beneficial effects on both LV function and the determinants of myocardial oxygen consumption.
在这些研究的背景下，有证据表明，在急性心肌梗死并发泵衰竭时，血管扩张剂治疗期间心脏功能可显著改善。尽管无并发症患者的临床病程良好，即使不进行积极的治疗干预，但采用标准方法（洋地黄和利尿剂）治疗的泵衰竭患者预后不佳。心脏功能中度降低的患者医院死亡率接近40%，而严重泵衰竭和/或心源性休克患者的死亡率可能高达100%。所提供的证据表明，早期谨慎的血管扩张剂治疗可能通过对左心室功能和心肌氧耗决定因素的有益作用，显著改变这种不良预后。
