Fasolini F
Chirurgische Klinik, Kantonsspital Aarau.
Zentralbl Chir. 1999;124(5):441-5.
Despite of improvement of results in rectum cancer treatment after systematical introduction of total mesorectal excision as a standard procedure to control the compartment disease, surgical radicality may be limited in cases with large tumours in ventral position because of eccentric location of the rectum in the perirectal fat. In these cases (neo)adjuvant treatment with a 45-54 Gy dose radiotherapy and 5 FU-based chemotherapy seems to be useful to minimize local recurrence and distant metastases and also to provide a better outcome.
尽管将全直肠系膜切除术作为控制区域疾病的标准手术系统引入后，直肠癌治疗效果有所改善，但由于直肠在直肠周围脂肪中的偏心位置，对于腹侧大肿瘤病例，手术根治性可能会受到限制。在这些病例中，采用45 - 54 Gy剂量的放疗和基于5 - FU的化疗进行（新）辅助治疗，似乎有助于将局部复发和远处转移降至最低，并获得更好的治疗效果。
