Konovalov A N, Pitskhelauri D I, Korshunov A G, Arutiunov N V, Imshenetskaia V F, Khukhlaeva E A
Zh Vopr Neirokhir Im N N Burdenko. 1999 Apr-Jun(2):33-6.
The paper describes the most infrequent case of cryptococcal granuloma of the midbrain in a HIV-negative female patient aged 41 years. The patient with midbrain lesion without signs of meningitis was found to have a bulky midbrain opercular formation that was regarded as a nodal glioma. The diagnosis of cryptococcal granuloma was established after removal of the formation (via occipito-transtentorial access with dissection of the lamina tecti) and pathomorphological examination. Microbiological studies verified the diagnosis. Despite the initiation of specific treatment with amphotericin B, the patient died on day 12 following surgery for cryptococcal meningoencephalitis.
本文描述了一名41岁HIV阴性女性患者中脑隐球菌肉芽肿这一极为罕见的病例。该患者有中脑病变但无脑膜炎体征,发现有一个巨大的中脑岛盖部结构,曾被认为是结节性胶质瘤。在切除该结构(通过枕下经小脑幕入路并切开顶盖)及进行病理形态学检查后,确诊为隐球菌肉芽肿。微生物学研究证实了诊断。尽管开始用两性霉素B进行特异性治疗,但患者在因隐球菌性脑膜脑炎手术后第12天死亡。