Falkner B, Michel S
MCP Hahnemann University, Philadelphia, Pennsylvania 19129-1191, USA.
Ethn Dis. 1999 Spring-Summer;9(2):284-9.
The prevalence of obesity has increased over the past three decades, in children as well as in adults. When obesity develops in the childhood years, excess adiposity generally continues into adult years, and adult obesity with childhood onset is frequently more severe. The health consequences of obesity in adults are well established, including greater rates of hypertension, non-insulin dependent diabetes mellitus, and heart disease. This paper will discuss the risk factors for these adult disorders that are detectable in obese children. Compared to normal weight children, obese children have higher blood pressure, higher plasma insulin levels, and a more atherogenic lipid pattern. Thus, the characteristic features of Syndrome X, or the insulin resistant syndrome, can be detected in obese children and adolescents. The vascular consequences of exposure to these metabolic risk factors beginning in childhood have yet to be completely determined. However, it is very likely that childhood obesity does contribute significantly to cardiovascular disease. For these reasons, greater efforts should be mounted to reduce the currently rising rates.
在过去三十年中,肥胖症在儿童和成人中的患病率均有所上升。儿童期出现肥胖时,多余的脂肪通常会持续到成年期,且成年后发病的肥胖症往往更为严重。肥胖对成年人健康的影响已得到充分证实,包括高血压、非胰岛素依赖型糖尿病和心脏病的发病率更高。本文将探讨在肥胖儿童中可检测到的这些成人疾病的危险因素。与正常体重儿童相比,肥胖儿童血压更高、血浆胰岛素水平更高,且血脂模式更易引发动脉粥样硬化。因此,在肥胖儿童和青少年中可检测到X综合征或胰岛素抵抗综合征的特征。儿童期开始接触这些代谢危险因素对血管的影响尚未完全确定。然而很有可能儿童肥胖确实对心血管疾病有显著影响。基于这些原因,应该做出更大努力来降低目前不断上升的发病率。