砷化镓（904纳米）激光辐射不影响小鼠骨骼肌的肌肉再生。
GaAs (904-nm) laser radiation does not affect muscle regeneration in mouse skeletal muscle.
作者信息
Oliveira N M, Parizzotto N A, Salvini T F
机构信息
Master Physical Therapy Program, Universidade Federal de São Carlos, 13565-905 São Carlos, SP, Brazil.
出版信息
Lasers Surg Med. 1999;25(1):13-21. doi: 10.1002/(sici)1096-9101(1999)25:1<13::aid-lsm3>3.0.co;2-7.
BACKGROUND AND OBJECTIVE
We evaluated the effect of GaAs (904-nm) laser, applied directly to the skin of injured muscle, in muscle regeneration.
STUDY DESIGN/MATERIAL AND METHODS: Muscle injury was induced in the Tibialis anterior (TA) muscle by ACL myotoxin (5 mg/kg). Two groups were irradiated with doses of 3 (n = 8) and 10 J/cm(2)(n = 8). GaAs laser (power 1.5 mW, intensity 7.5 mW/cm(2), spot 0.2 cm(2)) was applied daily for five days. Contralateral TA received a sham procedure.
RESULTS
Similar morphological aspects were found in both laser irradiated and sham muscles. No differences were found in the muscle weight, but animals irradiated with 10 J/cm(2) showed a significant gain of body weight (P = 0.002).
CONCLUSIONS
Doses of 3 and 10 J/cm(2) of GaAs laser were not efficient to promote significant morphological changes in the regenerated skeletal muscle, but the dose of 10 J/cm(2) promoted significant gain of body weight.
背景与目的
我们评估了直接作用于受伤肌肉皮肤的砷化镓（904纳米）激光对肌肉再生的影响。
研究设计/材料与方法：通过前交叉韧带肌毒素（5毫克/千克）诱导胫骨前肌（TA）损伤。两组分别接受3（n = 8）和10 J/cm²（n = 8）剂量的照射。每天使用砷化镓激光（功率1.5毫瓦，强度7.5毫瓦/平方厘米，光斑0.2平方厘米）照射，持续五天。对侧TA接受假手术。
结果
在激光照射组和假手术组肌肉中发现了相似的形态学特征。肌肉重量无差异，但接受10 J/cm²照射的动物体重显著增加（P = 0.002）。
结论
3和10 J/cm²剂量的砷化镓激光在促进再生骨骼肌显著形态学变化方面无效，但10 J/cm²剂量可促进体重显著增加。
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