Prázný M, Skrha J
III. interní klinika 1. LF UK a VFN, Praha.
Cas Lek Cesk. 1999 Apr 26;138(9):268-71.
Insulin-dependent diabetes mellitus is considered an autoimmune disease. The immune response is targeted on autoantigens of B-cells of the islets of Langerhans. The most important autoantigens are glutamic acid decarboxylase, protein tyrosine phosphatase and insulin. Despite the fact that their role in the pathogenesis of insulin-dependent diabetes mellitus is not clear, they are used in diagnosis and can identify subjects at high risk for the development of the disease.
胰岛素依赖型糖尿病被认为是一种自身免疫性疾病。免疫反应针对的是胰岛B细胞的自身抗原。最重要的自身抗原是谷氨酸脱羧酶、蛋白酪氨酸磷酸酶和胰岛素。尽管它们在胰岛素依赖型糖尿病发病机制中的作用尚不清楚，但它们可用于诊断，并能识别出患该病风险高的个体。
