Djurdjevic S, Devaja O, Hadzic B
Department of Obstetrics and Gynaecology, Medical School, University of Novi Sad, Yugoslavia.
Eur J Gynaecol Oncol. 1999;20(1):63-6.
A diagnostic and therapeutic approach in the identification of malignant lesions and the types of HPV in 11 patients with gigantic condylomatous vulvar protuberances is presented. Different histological types of squamous cell vulvar carcinoma have been found in 8 (72.7%) cases: condylomatous (4), verrucous (3) and basaloid type of the carcinoma (1). HPV type 16, confirmed in 5 cases, was most often present (4 condylomatous and 1 basaloid carcinoma types). Other types of HPV such as HPV-6 was detected in 3 cases of verrucous, type 11 in 2 cases of verrucous and condylomatous carcinoma and type 18 in 1 case of condylomatous carcinoma. Radical vulvectomy followed by bilateral inguinofemoral lymphadenectomy was performed in 4 patients with condylomatous carcinoma, hemivulvectomy in basaloid carcinoma whereas wide local excision was performed in the verrucous type of carcinoma. No patient died except 1 with condylomatous carcinoma in whom 6 positive lymph nodes were detected after the primary operation. The patient died 4 years later following 3 excisions of local recurrences.
本文介绍了对11例巨大外阴尖锐湿疣患者进行恶性病变及人乳头瘤病毒（HPV）类型鉴定的诊断和治疗方法。8例（72.7%）患者发现了不同组织学类型的外阴鳞状细胞癌：湿疣样（4例）、疣状（3例）和基底样癌（1例）。5例确诊为HPV-16型，最为常见（4例湿疣样癌和1例基底样癌）。其他HPV类型，如HPV-6在3例疣状癌中检测到，HPV-11在2例疣状癌和湿疣样癌中检测到，HPV-18在1例湿疣样癌中检测到。4例湿疣样癌患者行根治性外阴切除术加双侧腹股沟股淋巴结清扫术，基底样癌患者行半侧外阴切除术，疣状癌患者行广泛局部切除术。除1例湿疣样癌患者外，无患者死亡，该患者初次手术后发现6个阳性淋巴结。患者在3次局部复发切除术后4年死亡。
