Ueta Y, Hara Y, Setiadji V S, Isse T, Shibuya I, Kitamura K, Kangawa K, Matsuo H, Eto T, Hattori Y, Yamashita H
Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Peptides. 1999;20(2):199-204. doi: 10.1016/s0196-9781(98)00156-9.
Adrenomedullin-like immunoreactivity in the hypothalamo-neurohypophysial tract in colchicine-treated and hypophysectomized rats was examined by immunohistochemistry. Adrenomedullin-like immunoreactive (AM-LI) neurons were localized in the hypothalamic areas, including the paraventricular nuclei and the supraoptic nuclei. Abundant AM-LI fibers and varicosities were found in the hypothalamoneurohypophysial tract and the internal zone of the median eminence in the colchicine-treated and hypophysectomized rats, whereas in control rats few AM-LI fibers were observed. These results suggest that the axons of the AM-LI neurons in the hypothalamus may terminate in the neurohypophysis.
采用免疫组织化学方法检测了秋水仙碱处理及垂体切除大鼠下丘脑 - 神经垂体束中的肾上腺髓质素样免疫反应性。肾上腺髓质素样免疫反应性（AM-LI）神经元定位于下丘脑区域，包括室旁核和视上核。在秋水仙碱处理及垂体切除大鼠的下丘脑 - 神经垂体束和正中隆起内侧区发现了丰富的AM-LI纤维和膨体，而在对照大鼠中观察到的AM-LI纤维很少。这些结果表明，下丘脑AM-LI神经元的轴突可能终止于神经垂体。
