Atta M G, Whelton A
Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Am J Ther. 1997 Jan;4(1):55-60. doi: 10.1097/00045391-199701000-00011.
Several specific renal syndromes may be induced by the interaction of nonsteroidal anti-inflammatory drugs (NSAIDs) upon renal function. We report an NSAID-induced form of acute renal failure that represents a dual mechanism of impact on renal function involving direct parenchymal damage at a renal papillary level and mechanical outflow ureteric obstruction consequent to acute papillary necrosis. This form of NSAID-related acute renal failure has been reported very infrequently. We suspect the syndrome is not often recognized clinically. Clinicians and health care workers need to remind constantly the general public concerning the standard steps to be taken to ensure the proper and safe use of over-the-counter drugs. This is especially important considering the recent FDA approval of the over-the-counter sale of naproxen sodium, ketoprofen, and ibuprofen.
非甾体抗炎药（NSAIDs）与肾功能相互作用可能诱发几种特定的肾脏综合征。我们报告了一种由NSAIDs引起的急性肾衰竭形式，它代表了对肾功能的双重影响机制，包括肾乳头水平的直接实质损害以及急性乳头坏死导致的机械性输尿管流出道梗阻。这种与NSAIDs相关的急性肾衰竭形式报道极少。我们怀疑该综合征在临床上常未被识别。临床医生和医护人员需要不断提醒公众确保正确安全使用非处方药应采取的标准步骤。考虑到美国食品药品监督管理局（FDA）最近批准萘普生钠、酮洛芬和布洛芬非处方药销售，这一点尤为重要。
