[The effect of "cognitive" and "noncognitive" exposures on the sensitivity to stressor hormones and the choice of adaptation strategy].

Experimental data have shown that repeated exposure to both "cognitive" (recognized by the nervous system) and "noncognitive" (recognized by the immune system) stimuli induces so-called "tolerant (resource-preserving adaptation strategy". This strategy is characterized by enhanced hypoxia tolerance, reduced sensitivity to stress (catabolic) hormones, such as glucocorticoids and adrenomimetics, and increased sensitivity to insulin (central anabolic hormone). Such shifts appear more pronounced in case of "noncognitive" stimulation, which is also capable of inducing a hypocatabolic state. Nonspecific immunostimulation associated with repeated stress is considered as an appreciable stress-limiting process despite initial "cognitivity" of stressogenic stimulation.