Koval' S N, Starchenko T G, Gorb Iu G, Pen'kova M Iu, Khasanova Kh D
Lik Sprava. 1999 Jan-Feb(1):113-7.
Submitted in the paper are data on clinical, hemodynamic, and neurohumoral effects of monotherapy with an inhibitor of the angiotensin-converting enzyme berlipril (enalapril maleate) and a calcium antagonist of the benzothiazepine series retalzem (diltiazem resinate) versus their combination therapy. The combination therapy offers a number of important advantages over monotherapy with the above-named agents, consisting in apparent hypotensive action and a greater activation of endothelium-derived vasodilating and antiaggregation substances.
本文提交了关于血管紧张素转换酶抑制剂贝那普利（马来酸依那普利）和苯并噻氮䓬类钙拮抗剂瑞他唑嗪（树脂酸地尔硫䓬）单药治疗与其联合治疗的临床、血流动力学及神经体液效应的数据。与上述药物的单药治疗相比，联合治疗具有许多重要优势，包括明显的降压作用以及更大程度地激活内皮源性血管舒张和抗聚集物质。
