白色念珠菌对膀胱黏膜的黏附：组织外植体检测方法的建立与应用
Adherence of Candida albicans to bladder mucosa: development and application of a tissue explant assay.
作者信息
Lyman C A, Navarro E, Garrett K F, Roberts D D, Pizzo P A, Walsh T J
机构信息
Immunocompromised Host Section, National Cancer Institute, Bethesda, MD 20892, USA.
出版信息
Mycoses. 1999;42(4):255-9. doi: 10.1046/j.1439-0507.1999.00453.x.
In order to study the interactions between Candida species and uroepithelial tissue, a tissue explant assay was developed using bladder mucosa harvested from New Zealand white rabbits. Blastoconidia of Candida albicans, Candida tropicalis and Candida glabrata attached to the uroepithelial tissue in similar quantities. However, there was significantly more adherence to the uroepithelium by pre-germinated C. albicans compared with C. albicans blastoconidia. Furthermore, the amount of uroepithelial tissue injury was directly related to the length of exposure of the tissue to Candida. Thus, this tissue explant assay may provide a useful method for investigating properties related to fungal adherence to transitional uroepithelium and organism-mediated tissue injury.
为了研究念珠菌属与尿路上皮组织之间的相互作用，利用从新西兰白兔获取的膀胱黏膜开发了一种组织外植体检测方法。白色念珠菌、热带念珠菌和光滑念珠菌的芽生孢子以相似数量附着于尿路上皮组织。然而，与白色念珠菌芽生孢子相比，预萌发的白色念珠菌对尿路上皮的黏附明显更多。此外，尿路上皮组织损伤的程度与组织暴露于念珠菌的时间长短直接相关。因此，这种组织外植体检测方法可能为研究与真菌黏附于移行性尿路上皮及生物体介导的组织损伤相关的特性提供一种有用的方法。
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