Eliasen H, Kristensen H G, Schaefer T
The Royal Danish School of Pharmacy, Department of Pharmaceutics, 2 Universitetsparken, DK-2100, Copenhagen, Denmark.
Int J Pharm. 1999 Jul 5;184(1):85-96. doi: 10.1016/s0378-5173(99)00102-7.
Lactose monohydrate was melt agglomerated in an 8-l high shear mixer using stearic acid, polyethylene glycol (PEG) 3000, and a mixture of stearic acid and glycerol monostearate as meltable binders. Electrostatic charging during processing at relative air humidities of 35 and 75%, respectively, was estimated from the voltage of a monitoring probe inserted into the mixer. Stearic acid produced a high level of electrostatic charges, whereas PEG 3000 gave rise to a markedly lower level. Addition of glycerol monostearate to the stearic acid reduced the level of electrostatic charges. A correlation was found between the resistivity of the binder and the level of electrostatic charges in the material. With the stearic acid and the binder mixture, the level of electrostatic charges was higher at a low air humidity. The amount of adhesion to the bowl was found to depend on the level of electrostatic charges.
一水乳糖在一台8升的高剪切混合器中通过使用硬脂酸、聚乙二醇（PEG）3000以及硬脂酸和单硬脂酸甘油酯的混合物作为可熔性粘合剂进行熔融团聚。分别在相对空气湿度为35%和75%的加工过程中，通过插入混合器中的监测探头的电压来估算静电充电情况。硬脂酸产生了高水平的静电荷，而PEG 3000产生的静电荷水平明显较低。向硬脂酸中添加单硬脂酸甘油酯降低了静电荷水平。发现粘合剂的电阻率与材料中的静电荷水平之间存在相关性。对于硬脂酸和粘合剂混合物，在低空气湿度下静电荷水平更高。发现对混合器碗壁的粘附量取决于静电荷水平。
