Cheong Wai See, Heng Paul Wan Sia, Wong Tin Wui
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Pharm Dev Technol. 2007;12(4):371-80. doi: 10.1080/10837450701369311.
The present study aims to investigate the behavior of melt agglomeration with a low-viscosity hydrophobic meltable binder by using a non-meltable additive. The size, crushing strength, and pore size distribution of resultant agglomerates, the rheological, surface tension, and wetting properties of the molten binder, as well as, the flow characteristics of preagglomeration powder blend were determined. The use of additive showed contradictory agglomerate growth-promoting and -retarding effects on the molten binder surface tension and the interparticulate frictional forces. Critical concentration effects of additive corresponded to threshold transition of agglomeration-promoting to -retarding behavior were discussed.
本研究旨在通过使用不可熔融添加剂来研究低粘度疏水性可熔融粘合剂的熔体团聚行为。测定了所得团聚体的尺寸、抗压强度和孔径分布、熔融粘合剂的流变学、表面张力和润湿性,以及预团聚粉末混合物的流动特性。添加剂的使用对熔融粘合剂表面张力和颗粒间摩擦力显示出促进和阻碍团聚生长的矛盾作用。讨论了添加剂的临界浓度效应与团聚促进行为向阻碍行为的阈值转变相对应的情况。