Martinella-Catusse C, Nawrocki B, Gilles C, Birembaut P, Polette M
I.N.S.E.R.M. U. 514, Reims, France.
Histol Histopathol. 1999 Jul;14(3):839-43. doi: 10.14670/HH-14.839.
Matrix metalloproteinases (MMPs) represent a group of enzymes involved in the degradation of most of the components of the extracellular matrix and therefore participate in tumoural invasion. MMPs, especially gelatinases A and B, MT1-MMP, the activator of gelatinase A, and stromelysin-3 were found overexpressed in many cancers including bronchopulmonary carcinomas. In vivo observations revealed that fibroblasts are the principal source of production of MMPs. Some of these enzymes such as MT1-MMP and stromelysin 3, displayed a focal stromal localisation near preinvasive and invasive tumour clusters. Furthermore, some tumour cell lines were shown to stimulate the expression of MT1-MMP by fibroblasts. All these in vivo and in vitro results suggest that certain tumour cells produce diffusible factors which could influence the MMP stromal expression. Among these factors, the TCSF (Tumor Collagenase Stimulatory Factor) which is known to upregulate some MMPs in vitro could be a good candidate for this stromal regulation, since it is produced by bronchial tumour cells in vivo. In this review, we address such a cooperation between tumour and stromal cells for the production of MMPs and emphasize their necessity for tumoural progression in bronchopulmonary carcinomas.
基质金属蛋白酶（MMPs）是一组参与细胞外基质大多数成分降解的酶，因此参与肿瘤侵袭。在包括支气管肺癌在内的许多癌症中，发现MMPs，尤其是明胶酶A和B、MT1-MMP（明胶酶A的激活剂）和基质溶解素-3过表达。体内观察表明，成纤维细胞是MMPs的主要产生来源。其中一些酶，如MT1-MMP和基质溶解素3，在侵袭前和侵袭性肿瘤簇附近的基质中呈局灶性定位。此外，一些肿瘤细胞系被证明可刺激成纤维细胞表达MT1-MMP。所有这些体内和体外结果表明，某些肿瘤细胞产生可扩散因子，可能影响基质中MMPs的表达。在这些因子中，已知在体外可上调某些MMPs的肿瘤胶原酶刺激因子（TCSF）可能是这种基质调节的良好候选者，因为它在体内由支气管肿瘤细胞产生。在本综述中，我们探讨了肿瘤细胞与基质细胞在产生MMPs方面的这种合作，并强调它们在支气管肺癌肿瘤进展中的必要性。
