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[Thyroid disorders associated with interferon treatment in patients with chronic viral hepatitis or multiple sclerosis].

作者信息

Diago J I, del Olmo D, Alcázar V, Martínez de Icaya P, Rodríguez E, Martínez Montiel P

机构信息

Secciones de Endocrinología, Hospital Severo Ochoa, Leganés, Madrid.

出版信息

Med Clin (Barc). 1999 Jun 19;113(2):50-1.

PMID:10425619
Abstract

BACKGROUND

Alpha and beta interferon (IFN-alpha and beta) treatment is associated with the synthesis of thyroid autoantibodies and the development of autoimmune thyroid diseases.

METHODS AND RESULTS

We have retrospectively evaluated their effect in patients with chronic viral hepatitis (CH) (n = 118) and multiple esclerosis (ME) (n = 10). Thyroid dysfunction has been detected in 7.4% of patients, and seroconversion in 4.7%.

CONCLUSIONS

Pre-treatment antithyroid antibodies do not predispose to altered thyroid function, after IFN therapy; their presence should not contraindicate IFN treatment.

摘要

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