非钙依赖性磷脂酶A2在调节钙离子流入Jurkat细胞中的作用。
Role of calcium-independent phospholipase A2 in the regulation of calcium influx into Jurkat cells.
作者信息
Zabłocki K, Duszyński J
机构信息
Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland.
出版信息
Pol J Pharmacol. 1999 Mar-Apr;51(2):163-6.
PMID:10425645
Abstract
The role of phospholipases A2 in calcium metabolism is briefly reviewed. Some data are presented indicating that calcium-independent phospholipase A2 may modify the activity of store-activated calcium channels in the plasma membrane of Jurkat cells. Helss, a specific inhibitor of calcium-independent phospholipase A2 blocks the store-operated signal that is transmitted from ER to the plasma membrane.
摘要
本文简要综述了磷脂酶A2在钙代谢中的作用。文中给出了一些数据，表明不依赖钙的磷脂酶A2可能会改变Jurkat细胞膜中储存激活钙通道的活性。不依赖钙的磷脂酶A2的特异性抑制剂Helss可阻断从内质网传递至细胞膜的储存调控信号。
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