Herman Z S
Department of Clinical Pharmacology, Silesian University School of Medicine, Katowice, Poland.
Pol J Pharmacol. 1999 Mar-Apr;51(2):201-6.
In this review the calcium channel blockers (CCB) were divided into three generations. The advantages and shortcomings of these drugs were described. The application of CCB in the treatment of hypertensive disease, ischaemic heart disease, congestive heart failure and heart arrhythmias was discussed. Actually, the optimal drugs from this group are representatives of the third generation: amlodipine and lacidipine. It seems that search for new CCB should be directed to find the substances similar to or better than the chemical entities of this third generation. The calcium sensitizing agents as a new positive inotropic drugs are signalled. The possibility that in the future the new CCB could have an application as psychotropic drugs is mentioned.
在本综述中，钙通道阻滞剂（CCB）被分为三代。描述了这些药物的优缺点。讨论了CCB在治疗高血压病、缺血性心脏病、充血性心力衰竭和心律失常方面的应用。实际上，该类药物中的最佳药物是第三代的代表：氨氯地平和拉西地平。似乎寻找新型CCB应致力于找到与第三代化学实体相似或更优的物质。文中提到了钙敏化剂作为新型正性肌力药物。还提及了新型CCB未来有可能用作精神药物的可能性。
