Barron L G, Walzem R L, Hansen R J
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
Comp Biochem Physiol B Biochem Mol Biol. 1999 May;123(1):9-16. doi: 10.1016/s0305-0491(99)00032-2.
Blood plasma lipoproteins were studied during food and light deprivation or prolactin injection-induced involution of ovarian follicles (molt) of laying hens. Egg laying stopped 3 days after initiation of either treatment. Food and light-deprived hens lost 29% of initial body weight during the 10-day experiment (P < 0.05), whereas prolactin-treated hens lost 9% of body weight. Yolk-directed very low density lipoprotein (VLDLy) concentration in plasma decreased in both groups, but declined more rapidly in food and light-deprived hens. Very low density lipoprotein triacylglycerol decreased 40% in food and light-deprived hens by day 2 compared with a 13% decrease in the prolactin-treated hens. By day 5, a lipoprotein particle 21-22 nm in diameter appeared in the d = 1.019-1.046 g/ml density fraction of plasma in both groups. A similar lipoprotein particle, termed HDLR, developed in overfed hens with involuting ovarian follicles. In conclusion, hens undergoing ovarian regression due to food and light deprivation, prolactin treatment or overfeeding display marked decreases in plasma yolk-directed very low density lipoproteins and the appearance of HDLR. Other lipoprotein populations varied depending on whether the hens continued to feed or not.
研究了产蛋母鸡在食物和光照剥夺或催乳素注射诱导卵巢卵泡退化（换羽）期间的血浆脂蛋白情况。两种处理开始3天后产蛋停止。在为期10天的实验中，食物和光照剥夺的母鸡体重减轻了初始体重的29%（P < 0.05），而催乳素处理的母鸡体重减轻了9%。两组血浆中卵黄定向极低密度脂蛋白（VLDLy）浓度均下降，但在食物和光照剥夺的母鸡中下降得更快。与催乳素处理的母鸡13%的下降相比，食物和光照剥夺的母鸡到第2天时极低密度脂蛋白三酰甘油下降了40%。到第5天时，两组血浆d = 1.019 - 1.046 g/ml密度部分均出现了直径为21 - 22 nm的脂蛋白颗粒。在卵巢卵泡退化的过度喂养母鸡中也出现了类似的脂蛋白颗粒，称为HDLR。总之，由于食物和光照剥夺、催乳素处理或过度喂养而经历卵巢退化的母鸡，其血浆卵黄定向极低密度脂蛋白显著减少，并出现HDLR。其他脂蛋白群体则根据母鸡是否继续进食而有所不同。
