Seaton B E, Allen D N, Goldstein G, Kelley M E, van Kammen D P
Department of Psychiatry, University of Rochester School of Medicine and Dentistry, New York, USA.
J Nerv Ment Dis. 1999 Jul;187(7):414-9. doi: 10.1097/00005053-199907000-00004.
Although numerous studies have consistently revealed cognitive heterogeneity in schizophrenia, the relationships between such heterogeneity and clinical phenomenology are not clear. Clusters derived from cognitive heterogeneity studies may or may not be associated with symptom profile or severity of illness. The purpose of this study was to examine the relationship between cognitive heterogeneity and demographic and clinical phenomenological measures. We examined cognitive heterogeneity in schizophrenia by empirically deriving clusters of patients based upon WAIS-R subtest scores and then analyzed the way in which these clusters related to demographic and symptom variables and to DSM-III-R diagnostic subtypes. Four cognitive clusters were identified that were consistent with previous research. These clusters were differentiated on the basis of educational level and occupational status but not on the basis of symptom profile, severity, or DSM-III-R subtypes. Results suggest that cognitive measures are independent of severity of the disorder and phenomenological symptom presentation in these subgroups of schizophrenic patients.
尽管众多研究一直揭示精神分裂症存在认知异质性，但这种异质性与临床现象学之间的关系尚不清楚。认知异质性研究得出的集群可能与症状特征或疾病严重程度相关，也可能无关。本研究的目的是检验认知异质性与人口统计学及临床现象学指标之间的关系。我们通过根据韦氏成人智力量表修订版（WAIS-R）子测验分数对患者进行实证聚类来研究精神分裂症中的认知异质性，然后分析这些集群与人口统计学和症状变量以及与《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）诊断亚型之间的关联方式。确定了四个与先前研究一致的认知集群。这些集群在教育水平和职业状况的基础上有所区分，但在症状特征、严重程度或DSM-III-R亚型的基础上并无差异。结果表明，在这些精神分裂症患者亚组中，认知指标与疾病严重程度及现象学症状表现无关。
