Lemière J, Van Gool D, Dom R
Department of Neurology, U.Z. Gasthuisberg, Leuven.
Acta Neurol Belg. 1999 Jun;99(2):96-106.
The cholinergic hypothesis claims that a decrease of acetylcholine (ACh) in the brain of patients with Alzheimer's Disease (AD) plays an important role in the deterioration of cognitive functioning. This hypothesis has led to extensive research in possible therapeutic approaches towards improving cholinergic transmission in AD patients. The different approaches have focused on the following six strategies: ACh precursors, ACh release, M1, M3, or M4 receptor agonists, M2 receptor antagonists, nicotinic agonists, and acetylcholinesterase inhibitors (AChEI). The aim of this review is to assess the effectiveness of the cholinergic approach for the treatment of AD.
胆碱能假说认为，阿尔茨海默病（AD）患者大脑中乙酰胆碱（ACh）的减少在认知功能衰退中起重要作用。这一假说引发了对改善AD患者胆碱能传递的可能治疗方法的广泛研究。不同方法聚焦于以下六种策略：ACh前体、ACh释放、M1、M3或M4受体激动剂、M2受体拮抗剂、烟碱激动剂以及乙酰胆碱酯酶抑制剂（AChEI）。本综述的目的是评估胆碱能方法治疗AD的有效性。
