尼古丁对大鼠离体肾动脉的舒张作用。

The relaxation induced by nicotine in the rat isolated renal artery.

作者信息

Emre S, Ay I, Tuncer M

机构信息

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, Turkey.

出版信息

Gen Pharmacol. 1999 Jul;33(1):23-7. doi: 10.1016/s0306-3623(98)00268-7.

DOI:10.1016/s0306-3623(98)00268-7

PMID:10428012

Abstract

The mechanism of nicotine-induced relaxation was investigated in the rat isolated renal artery. Nicotine (10(-3) M) produced a relaxation when preparations were precontracted by phenylephrine (3 x 10(-6) M). Nicotine-induced relaxation was 27.3 +/- 2.5% of phenylephrine contraction and was not affected by atropine (10(-5) M), guanethidine (10(-5) M), hexamethonium (10(-4) M), indomethacin (10(-5) M), N(G)-nitro-L-arginine (10(-4) M), methylene blue (10(-5) M), glibenclamide (10(-5) M), quinacrine (3 x 10(-6) M), tetrodotoxin (10(-6) M), capsaicin (10(-6) M), tetraethylammonium (10(-3) M), 4-aminopyridine (10(-3) M), and ouabain (10(-6) M) (n = 6, Mann-Whitney U-test). A calcium antagonizing effect of nicotine was not observed. Therefore, it appears that nicotine relaxes rat isolated renal artery by a nonspecific action on the vascular smooth muscle.

摘要

在大鼠离体肾动脉中研究了尼古丁诱导舒张的机制。当标本用去氧肾上腺素（3×10⁻⁶ M）预收缩时，尼古丁（10⁻³ M）产生了舒张作用。尼古丁诱导的舒张作用为去氧肾上腺素收缩作用的27.3±2.5%，且不受阿托品（10⁻⁵ M）、胍乙啶（10⁻⁵ M）、六甲铵（10⁻⁴ M）、吲哚美辛（10⁻⁵ M）、N(G)-硝基-L-精氨酸（10⁻⁴ M）、亚甲蓝（10⁻⁵ M）、格列本脲（10⁻⁵ M）、奎纳克林（3×10⁻⁶ M）、河豚毒素（10⁻⁶ M）、辣椒素（10⁻⁶ M）、四乙铵（10⁻³ M）、4-氨基吡啶（10⁻³ M）和哇巴因（10⁻⁶ M）的影响（n = 6，曼-惠特尼U检验）。未观察到尼古丁的钙拮抗作用。因此，尼古丁似乎通过对血管平滑肌的非特异性作用使大鼠离体肾动脉舒张。