一名10岁女孩患有分泌促卵泡生成素的促性腺激素细胞腺瘤并伴有卵巢肿大。
A follicle-stimulating hormone-secreting gonadotroph adenoma with ovarian enlargement in a 10-year-old girl.
作者信息
Tashiro H, Katabuchi H, Ohtake H, Kaku T, Ushio Y, Okamura H
机构信息
Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Kumamoto-City, Japan.
出版信息
Fertil Steril. 1999 Jul;72(1):158-60. doi: 10.1016/s0015-0282(99)00197-1.
OBJECTIVE
To report a rare case of gonadotroph adenoma accompanied by ovarian enlargement in a child.
DESIGN
Case report.
SETTING
A university hospital.
PATIENT(S): A 10-year-old Japanese girl with multiple cysts of both ovaries.
INTERVENTION(S): Endocrinologic assays, immunohistochemical staining, ultrastructural observations, and in vitro analysis.
MAIN OUTCOME MEASURE(S): The endocrinologic assays showed an elevated serum FSH level. The tumor cells excised from the gonadotroph adenoma were immunohistochemically positive for antihuman FSH monoclonal antibody. When cultured in vitro, the tumor cells secreted FSH in the primary culture.
RESULT(S): The gonadotroph adenoma produced FSH. After transsphenoidal surgery, both ovaries decreased in size.
CONCLUSION(S): The ovarian enlargement was induced by endogenous FSH from the gonadotroph adenoma. To our knowledge, this is the first reported case of gonadotroph adenoma accompanied by ovarian enlargement in childhood or adolescence.
目的
报告一例儿童促性腺激素腺瘤伴卵巢增大的罕见病例。
设计
病例报告。
地点
一所大学医院。
患者
一名10岁的日本女孩，双侧卵巢有多个囊肿。
干预措施
内分泌测定、免疫组织化学染色、超微结构观察和体外分析。
主要观察指标
内分泌测定显示血清促卵泡激素（FSH）水平升高。从促性腺激素腺瘤切除的肿瘤细胞经免疫组织化学检测，抗人FSH单克隆抗体呈阳性。在体外培养时，肿瘤细胞在原代培养中分泌FSH。
结果
促性腺激素腺瘤产生FSH。经蝶窦手术后，双侧卵巢体积减小。
结论
卵巢增大是由促性腺激素腺瘤分泌的内源性FSH所致。据我们所知，这是首例报道的儿童或青少年期促性腺激素腺瘤伴卵巢增大的病例。
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