Sciarra A, Casale P, Di Nicola S, Di Chiro C, Colella D, Di Silverio F
Dipartimento di Urologia U. Bracci, Università degli Studi di Roma, La Sapienza.
Minerva Urol Nefrol. 1999 Jun;51(2):105-12.
Recent data suggest that PSA expression can be directly influenced by some factors, independently from the variation in prostate cell growth. Some growth factors such as fibroblast growth factor, transforming growth factor beta and epidermal growth factor, seem to be directly involved in the regulation of mRNA-PSA expression, whereas androgens could have an indirect activity. On the basis of these experimental data, this review tries to analyze some limits of PSA and some recent data on the role of PSA-isoforms, in particular in the follow-up of prostate cancer patients submitted to radical prostatectomy or hormone-therapy. Moreover, relevant informations can be obtained analyzing the variance of PSA in patients submitted to intermittent androgen deprivation.
最近的数据表明，前列腺特异性抗原（PSA）的表达可直接受某些因素影响，而与前列腺细胞生长的变化无关。一些生长因子，如成纤维细胞生长因子、转化生长因子β和表皮生长因子，似乎直接参与mRNA-PSA表达的调节，而雄激素可能具有间接作用。基于这些实验数据，本综述试图分析PSA的一些局限性以及关于PSA异构体作用的一些最新数据，特别是在接受根治性前列腺切除术或激素治疗的前列腺癌患者的随访中。此外，通过分析接受间歇性雄激素剥夺治疗患者的PSA变化，可以获得相关信息。
