Go T
Department of Pediatrics, Otsu Red Cross Hospital, Shiga.
No To Hattatsu. 1999 Jul;31(4):366-9.
I reported here girl with localization-related epilepsy who developed particular involuntary movements (IVMs) with a therapeutic dosis of carbamazepine. An epileptic seizure, loss of consciousness followed by a tonic-clonic seizure on the left, occurred at 9 and half years and carbamazepine was administrated. With the blood levels of 9.3 micrograms/ml (4 hours after administration), oral dyskinesia, choreiform movements of fingers of both sides, and myoclonus of the left arm developed. These IVMs disappeared soon after the decrease of the dosis (5.8 micrograms/ml, 6 hours after administration). As there was no other clinical and laboratory findings responsible for these IVMs, carbamazepine was thought to be the causative agent for them. The neurons and neural system related to the localization-related epilepsy may also have been involved.
我在此报告一名患有与定位相关癫痫的女孩，她在服用治疗剂量的卡马西平后出现了特定的不自主运动（IVM）。该女孩9岁半时发生癫痫发作，先是意识丧失，随后左侧出现强直阵挛发作，之后开始服用卡马西平。服药4小时后血药浓度为9.3微克/毫升时，出现了口部运动障碍、双侧手指舞蹈样动作以及左臂肌阵挛。剂量减少后（服药6小时后血药浓度为5.8微克/毫升），这些不自主运动很快消失。由于没有其他临床和实验室检查结果可解释这些不自主运动，因此认为卡马西平是其病因。与定位相关癫痫有关的神经元和神经系统可能也参与其中。
