Fahey J V, Prabhala R H, Guyre P M, Wira C R
Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA.
Am J Reprod Immunol. 1999 Jul;42(1):49-57. doi: 10.1111/j.1600-0897.1999.tb00465.x.
To determine whether cells in the female reproductive tract (FRT) are functionally capable of presenting antigen to T cells.
Analysis was done by determining the proliferation of purified autologous T cells to antigen, following co-incubation with non-proliferating cell suspensions isolated from the uterus and prepared by enzymatic digestion of reproductive tract tissues from hysterectomy patients with benign disease.
All uterine preparations analyzed were functionally capable of presenting antigen; the ability to present antigen was independent of pre- and post-menopausal status. In contrast, some, but not all, tissues from the ovary, Fallopian tube, cervix, and vagina were capable of presenting antigen.
These results suggest that the human FRT is an inductive site for immune responses. Regulation of antigen presentation in the reproductive tract may be important for protection against sexually transmitted diseases.
确定女性生殖道（FRT）中的细胞在功能上是否能够将抗原呈递给T细胞。
通过将纯化的自体T细胞与从子宫分离的非增殖细胞悬液共同孵育后，测定其对抗原的增殖情况进行分析。该细胞悬液由患有良性疾病的子宫切除患者的生殖道组织经酶消化制备而成。
所有分析的子宫制剂在功能上都能够呈递抗原；呈递抗原的能力与绝经前和绝经后状态无关。相比之下，卵巢、输卵管、子宫颈和阴道的一些（但不是全部）组织能够呈递抗原。
这些结果表明，人类FRT是免疫反应的诱导部位。生殖道中抗原呈递的调节对于预防性传播疾病可能很重要。
