Imada T, Rino Y, Takahashi M, Hatori S, Shiozawa M, Amano T, Kondo J
First Department of Surgery, Yokohama City University, Japan.
Hepatogastroenterology. 1999 May-Jun;46(27):2086-90.
BACKGROUND/AIMS: This study was conducted to elucidate the relationship between the seropositive rates of Carcinoembryonic antigen (CEA), Sialyl Le(a) (CA 19-9), Sialyl Le(x) (SLX) and Sialyl Tn (STN) and the clinicopathological variables. The correlation of serum levels of these antigens between the peripheral venous blood and the venous blood draining from the tumor was also evaluated.
The subjects were 113 patients with gastric cancer, who underwent gastrectomy at the First Department of Surgery, Yokohama City University, between 1991 and 1996. Serum levels of CA 19-9, SLX, STN and CEA in the peripheral blood and the draining venous blood were measured.
The positive rates for CA 19-9, SLX, STN and CEA were closely correlated with tumor stage, lymph node metastasis, and depth of invasion. Although the seropositive rates for CA 19-9, SLX, STN, and CEA in the draining venous blood were lower than those in the peripheral blood, a close correlation for serum levels of 4 antigens between the peripheral venous blood and the draining venous blood was observed in advanced cancer.
These results suggest that these antigens may be drained by the lymphatic route as well as the hematogenous route. Further studies must be performed to elucidate the mechanism of these antigens entering into the peripheral blood by devising a technique for collecting the lymph.
背景/目的：本研究旨在阐明癌胚抗原（CEA）、唾液酸化Le(a)（CA 19-9）、唾液酸化Le(x)（SLX）和唾液酸化Tn（STN）的血清阳性率与临床病理变量之间的关系。同时还评估了这些抗原在周围静脉血和肿瘤引流静脉血之间的血清水平相关性。
研究对象为1991年至1996年间在横滨市立大学第一外科接受胃切除术的113例胃癌患者。检测外周血和引流静脉血中CA 19-9、SLX、STN和CEA的血清水平。
CA 19-9、SLX、STN和CEA的阳性率与肿瘤分期、淋巴结转移及浸润深度密切相关。虽然引流静脉血中CA 19-9、SLX、STN和CEA的血清阳性率低于外周血，但在进展期癌中观察到外周静脉血与引流静脉血中4种抗原的血清水平密切相关。
这些结果表明，这些抗原可能通过淋巴途径和血行途径排出。必须通过设计一种收集淋巴的技术来进一步研究阐明这些抗原进入外周血的机制。
