Neurodegenerative diseases of Guam: analysis of TAU.

作者信息

Pérez-Tur J, Buée L, Morris H R, Waring S C, Onstead L, Wavrant-De Vrièze F, Crook R, Buée-Scherrer V, Hof P R, Petersen R C, McGeer P L, Delacourte A, Hutton M, Siddique T, Ahlskog J E, Hardy J, Steele J C

机构信息

Mayo Clinic Department of Pharmacology, Jacksonville, FL 32224, USA.

出版信息

Neurology. 1999 Jul 22;53(2):411-3. doi: 10.1212/wnl.53.2.411.

DOI:10.1212/wnl.53.2.411

PMID:10430438

Abstract

Mutations in the tau gene have been described in families affected by frontotemporal dementia with parkinsonism linked to chromosome 17. The authors performed a genetic and biochemical analysis of this gene and its product in the parkinsonism dementia complex of Guam, a disorder characterized by the extensive formation of neurofibrillary tangles. The tau gene is not a primary cause of the parkinsonism dementia complex of Guam.

摘要