糖基磷脂酰肌醇微结构域：在通过免疫受体进行信号传导中的作用。

GPI-microdomains: a role in signalling via immunoreceptors.

作者信息

Horejsí V, Drbal K, Cebecauer M, Cerný J, Brdicka T, Angelisová P, Stockinger H

机构信息

Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 142 20 Prague 4, V denská 1083, Czech Republic.

出版信息

Immunol Today. 1999 Aug;20(8):356-61. doi: 10.1016/s0167-5699(99)01489-9.

DOI:10.1016/s0167-5699(99)01489-9

PMID:10431155

Abstract

Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kinases, G-proteins, linker proteins). Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors.

摘要

糖基磷脂酰肌醇（GPI）锚定蛋白和糖鞘脂在膜微结构域内组装于白细胞表面，这些膜微结构域还容纳一组细胞质信号分子（Src家族激酶、G蛋白、连接蛋白）。最近的研究结果表明，这些膜特化结构不仅介导通过GPI蛋白和糖脂的信号转导，而且在通过免疫受体启动信号传导中也发挥重要作用。