Kinoshita Taroh, Fujita Morihisa, Maeda Yusuke
WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan.
J Biochem. 2008 Sep;144(3):287-94. doi: 10.1093/jb/mvn090. Epub 2008 Jul 17.
More than 100 mammalian proteins are post-translationally modified by glycosylphosphatidylinositol (GPI) at their C-termini and are anchored to the cell surface membrane via the lipid portion. GPI-anchored proteins (GPI-APs) have various functions, such as hydrolytic enzymes, receptors, adhesion molecules, complement regulatory proteins and other immunologically important proteins. GPI-anchored proteins are mainly associated with membrane microdomains or membrane rafts enriched in sphingolipids and cholesterol. It is thought that association with membrane rafts is important for GPI-APs in signal transduction and other functions. Here, we review recent progress in studies on biosynthesis, remodelling and functions of mammalian GPI-APs.
100多种哺乳动物蛋白质在其C末端通过糖基磷脂酰肌醇（GPI）进行翻译后修饰，并通过脂质部分锚定在细胞表面膜上。GPI锚定蛋白（GPI-APs）具有多种功能，如水解酶、受体、粘附分子、补体调节蛋白和其他免疫重要蛋白。GPI锚定蛋白主要与富含鞘脂和胆固醇的膜微区或膜筏相关。人们认为与膜筏的结合对于GPI-APs在信号转导和其他功能中很重要。在这里，我们综述了哺乳动物GPI-APs在生物合成、重塑和功能研究方面的最新进展。
