Hamberg M, Svensson J, Blombäck M
Prostaglandins Med. 1978 Dec;1(6):455-60. doi: 10.1016/0161-4630(78)90116-7.
Platelet suspensions obtained at different time intervals following a single dose of oral aspirin were incubated with [1-(14)C]-arachidonic acid and the amount of [1-(14)C]thromboxane B2 formed was determined by a double isotope technique. Since aspirin is an irreversible inhibitor of platelet cyclooxygenase and since circulating platelets do not synthesize cyclooxygenase the rate of reappearance of active cyclooxygenase determined in this way was a measure of the rate of regeneration of functioning platelets. In two subjects the regeneration half-times were 4.2 and 4.8 days.
在单次口服阿司匹林后的不同时间间隔采集血小板悬液，与[1-(14)C] - 花生四烯酸一起孵育，并用双同位素技术测定形成的[1-(14)C]血栓素B2的量。由于阿司匹林是血小板环氧化酶的不可逆抑制剂，且循环血小板不合成环氧化酶，因此以这种方式测定的活性环氧化酶重新出现的速率是功能性血小板再生速率的一种度量。在两名受试者中，再生半衰期分别为4.2天和4.8天。
