Ramage I J, Geary D F, Harvey E, Secker D J, Balfe J A, Balfe J W
Division of Paediatric Nephrology, The Hospital for Sick Children and University of Toronto, Ontario, Canada.
Perit Dial Int. 1999 May-Jun;19(3):231-6.
To assess the efficacy of supplemental gastrostomy tube (g-tube) feeding in infants and children receiving chronic peritoneal dialysis (CPD).
Retrospective observational study.
Pediatric nephrology division of tertiary care center.
Fifteen patients undergoing g-tube insertion while receiving CPD were included in the study, and were subdivided, on the basis of age, into the following groups: infants (< or = 2.5 years, n = 8); older children (> 2.5 years, n = 7).
Assessment of the effect of CPD and g-tube feeding on statural growth assessed by height standard deviation score (SDS) and percentage weight-for-height, and measured anthropometric variables including triceps skinfold thickness (TSF), midarm muscle circumference (MAMC), and midarm mean circumference (MAC). Assessment of the effects of CPD and g-tube feeding on measured biochemical variables including total protein, albumin, cholesterol, triglycerides, and high density lipoprotein.
No significant change in height SDS was observed; however, the reported continuing decline in height SDS in infants was arrested. Percentage weight-for-height increased significantly in infants at 6 months (p = 0.008) and 12 months (p = 0.006) following initiation of g-tube feeding. An increase was also observed in the older child group, being significant at 12 months (p = 0.031) following g-tube insertion. Increases in all anthropometric variables occurred in the infant group during CPD and post g-tube insertion, significant only for MAMC at 12 months (p = 0.037) post g-tube insertion. In older children little change occurred during CPD, with all variables increasing post g-tube insertion, significant only for MAMC at 6 months (p = 0.02) and 12 months (p = 0.02). An increase in total protein and albumin was noted; however, no significant changes in any biochemical parameters were observed.
Supplemental g-tube feeding facilitates weight gain in infants and older children receiving CPD and arrests the decline in height SDS traditionally observed in infants with end-stage renal disease. No significant alteration was observed in measured biochemical variables, although an increase in total protein and albumin was noted.
评估补充胃造口管（胃管）喂养对接受慢性腹膜透析（CPD）的婴幼儿和儿童的疗效。
回顾性观察研究。
三级医疗中心的儿科肾脏病科。
15例在接受CPD期间接受胃管插入术的患者纳入研究，并根据年龄分为以下几组：婴儿（≤2.5岁，n = 8）；大龄儿童（> 2.5岁，n = 7）。
通过身高标准差评分（SDS）和身高体重百分比评估CPD和胃管喂养对身高增长的影响，并测量人体测量学变量，包括三头肌皮褶厚度（TSF）、上臂中部肌肉周长（MAMC）和上臂中部平均周长（MAC）。评估CPD和胃管喂养对测量的生化变量的影响，包括总蛋白、白蛋白、胆固醇、甘油三酯和高密度脂蛋白。
未观察到身高SDS有显著变化；然而，报告显示婴儿身高SDS持续下降的情况得到了遏制。开始胃管喂养后6个月（p = 0.008）和12个月（p = 0.006）时，婴儿的身高体重百分比显著增加。大龄儿童组也观察到增加，在胃管插入后12个月时显著（p = 0.031）。婴儿组在CPD期间和胃管插入后所有人体测量学变量均增加，仅在胃管插入后12个月时MAMC显著增加（p = 0.037）。大龄儿童在CPD期间变化不大，胃管插入后所有变量均增加，仅在6个月（p = 0.02）和12个月（p = 0.02）时MAMC显著增加。总蛋白和白蛋白有所增加；然而，未观察到任何生化参数有显著变化。
补充胃管喂养有助于接受CPD的婴幼儿和大龄儿童体重增加，并遏制了终末期肾病婴儿传统上观察到的身高SDS下降。尽管总蛋白和白蛋白有所增加，但未观察到测量的生化变量有显著改变。
