Schmachtenberg O, Bacigalupo J
Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.
Brain Res. 1999 Aug 7;837(1-2):301-5. doi: 10.1016/s0006-8993(99)01635-2.
The putative role of nitric oxide (NO) in the physiology of olfactory receptor neurons (ORNs) is controversial. Here we report that pulses of NO caused an outward current in voltage-clamped isolated olfactory neurons. The I-V relation of this effect, its sensitivity to charybdotoxin and its dependence on external potassium suggest that NO activates a K(+)-conductance. As blockers of soluble guanylyl cyclases failed to affect the current, we conclude that NO opens K(+)-channels in a cGMP-independent manner.
一氧化氮（NO）在嗅觉受体神经元（ORN）生理学中的假定作用存在争议。在此我们报告，NO脉冲在电压钳制的离体嗅觉神经元中引起外向电流。这种效应的电流-电压关系、对蝎毒素的敏感性及其对细胞外钾的依赖性表明，NO激活了一种钾离子电导。由于可溶性鸟苷酸环化酶的抑制剂未能影响该电流，我们得出结论，NO以不依赖环磷酸鸟苷（cGMP）的方式打开钾离子通道。
