Fowler J C, Gervitz L, Partridge L D
Department of Physiology, Texas Tech University Health Sciences Center, School of Medicine, 3601 4th Street, Lubbock, TX 79430, USA.
Brain Res. 1999 Aug 7;837(1-2):309-13. doi: 10.1016/s0006-8993(99)01659-5.
The commonly used nitric oxide donor, hydroxylamine (NH(2)OH), can block or reverse the inhibition of glutamatergic transmission by adenosine or an adenosine A(1) agonist in rat hippocampal slice. In these experiments, hydroxylamine did not affect the adenosine A(1) receptor-mediated depression of postsynaptic excitability. We conclude that hydroxylamine acts presynaptically to counter adenosine A(1) receptor-mediated inhibition of synaptic transmission.
常用的一氧化氮供体羟胺（NH₂OH）可阻断或逆转大鼠海马切片中腺苷或腺苷A₁激动剂对谷氨酸能传递的抑制作用。在这些实验中，羟胺并未影响腺苷A₁受体介导的突触后兴奋性抑制。我们得出结论，羟胺通过作用于突触前，来对抗腺苷A₁受体介导的突触传递抑制。
