Maeda M, Kosaka Y, Kushizaki H, Yamamori Y, Hashimoto K, Saito Y
Department of Anesthesiology, Shimane Medical University, Izumo.
Masui. 1999 Jul;48(7):723-30.
To confirm the safety of continuous epidural anesthesia during extracorporeal circulation under heparinization, we investigated epidural hematoma formation following the cardiopulmonary bypass in both humans and dogs. In fifteen dogs, divided into three groups, heparin was administered at the dose of 300, 600, or 900 U.kg-1, respectively. In fourteen patients, a dose of 300 U.kg-1 haparin was administered for cardiopulmonary bypass. Although blood coagulation-fibrinolysis dropped into abnormal ranges following heparinization, no epidural hematoma was observed in dog and no patient revealed spinal complication associated with epidural hematoma. These data indicate that continuous epidural anesthesia would be a safe tool for intraoperative anesthesia even during extracorporeal circulation under heparinization.
为证实肝素化体外循环期间连续硬膜外麻醉的安全性，我们研究了人和犬体外循环后硬膜外血肿的形成情况。将15只犬分为三组，分别给予300、600或900 U.kg-1剂量的肝素。14例患者在体外循环时给予300 U.kg-1剂量的肝素。尽管肝素化后凝血-纤溶指标降至异常范围，但犬未观察到硬膜外血肿，患者也未出现与硬膜外血肿相关的脊髓并发症。这些数据表明，即使在肝素化体外循环期间，连续硬膜外麻醉仍是术中麻醉的一种安全方法。
