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Raloxifene as a multifunctional medicine? Current trials will show whether it is effective in both osteoporosis and breast cancer.

作者信息

Jordan V C, Morrow M

出版信息

BMJ. 1999 Aug 7;319(7206):331-2. doi: 10.1136/bmj.319.7206.331.

DOI:10.1136/bmj.319.7206.331
PMID:10435938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1126973/
Abstract
摘要

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Raloxifene as a multifunctional medicine? Current trials will show whether it is effective in both osteoporosis and breast cancer.雷洛昔芬是一种多功能药物？目前的试验将表明它对骨质疏松症和乳腺癌是否都有效。
BMJ. 1999 Aug 7;319(7206):331-2. doi: 10.1136/bmj.319.7206.331.
2
[Estrogen agonists, especially raloxifene, in the treatment of osteoporosis].[雌激素激动剂，尤其是雷洛昔芬，用于治疗骨质疏松症]
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3
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4
Patterns of physician-reported diagnoses for women receiving raloxifene prescriptions.
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5
Osteoporosis drugs show early promise.
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6
Raloxifene provides an alternative for osteoporosis prevention.雷洛昔芬为骨质疏松症的预防提供了一种替代方法。
Ann Pharmacother. 1998 Jul-Aug;32(7-8):834-7. doi: 10.1345/aph.17335.
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Phase II evaluation of Ly156758 in metastatic breast cancer.Ly156758用于转移性乳腺癌的II期评估。
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[Raloxifene: a new molecule for the prevention of menopausal osteoporosis].
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Designer estrogens: breast cancer benefit, remaining questions.设计雌激素：对乳腺癌有益，仍存疑问。
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A new day dawns: women without oestrogen or is a balance best?新的一天来临：无雌激素的女性还是保持平衡更佳？
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Recent advances: rheumatology.最新进展：风湿病学

本文引用的文献

1
The effect of raloxifene on risk of breast cancer in postmenopausal women: results from the MORE randomized trial. Multiple Outcomes of Raloxifene Evaluation.雷洛昔芬对绝经后妇女乳腺癌风险的影响：MORE随机试验结果。雷洛昔芬评估的多项结果
JAMA. 1999 Jun 16;281(23):2189-97. doi: 10.1001/jama.281.23.2189.
2
Tamoxifen, raloxifene, and the prevention of breast cancer.他莫昔芬、雷洛昔芬与乳腺癌预防
Endocr Rev. 1999 Jun;20(3):253-78. doi: 10.1210/edrv.20.3.0368.
3
Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.
BMJ. 2000 Oct 7;321(7265):882-5. doi: 10.1136/bmj.321.7265.882.
他莫昔芬预防乳腺癌：国家外科辅助乳腺和肠道项目P-1研究报告。
J Natl Cancer Inst. 1998 Sep 16;90(18):1371-88. doi: 10.1093/jnci/90.18.1371.
4
Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.他莫昔芬用于早期乳腺癌：随机试验综述。早期乳腺癌试验者协作组
Lancet. 1998 May 16;351(9114):1451-67.
5
Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women.雷洛昔芬对健康绝经后女性血清脂质及凝血因子的影响。
JAMA. 1998 May 13;279(18):1445-51. doi: 10.1001/jama.279.18.1445.
6
Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women.雷洛昔芬对绝经后妇女骨矿物质密度、血清胆固醇浓度及子宫内膜的影响。
N Engl J Med. 1997 Dec 4;337(23):1641-7. doi: 10.1056/NEJM199712043372301.
7
Proportion of breast cancer cases in the United States explained by well-established risk factors.美国乳腺癌病例中由已明确的风险因素所解释的比例。
J Natl Cancer Inst. 1995 Nov 15;87(22):1681-5. doi: 10.1093/jnci/87.22.1681.
8
Effects of anti-estrogens on bone in castrated and intact female rats.抗雌激素对去势和未去势雌性大鼠骨骼的影响。
Breast Cancer Res Treat. 1987 Oct;10(1):31-5. doi: 10.1007/BF01806132.
9
Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model.凯昔芬和他莫昔芬在N-亚硝基甲基脲诱导的大鼠乳腺癌模型中的抗肿瘤作用。
Cancer Res. 1987 Aug 1;47(15):4020-4.
10
A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer.一项评估他莫昔芬预防乳腺癌的急性毒性和可行性的试点试验。
Br J Cancer. 1989 Jul;60(1):126-31. doi: 10.1038/bjc.1989.235.