地塞米松对孤束核中去甲肾上腺素诱导的心血管反应的影响。
Effect of dexamethasone on cardiovascular response induced by norepinephrine in nucleus tractus solitarii.
作者信息
Ou-Yang M, Ge G H, Wang S
机构信息
Department of Physiology, Norman Bethune University of Medical Sciences, Changchun, China.
出版信息
Zhongguo Yao Li Xue Bao. 1999 Feb;20(2):167-70.
AIM
To study the effect of dexamethasone on cardiovascular response induced by norepinephrine (NE) in nucleus tractus solitarii (NTS).
METHODS
The variations of cardiovascular action caused by these drugs were observed after injection of mifepristone (Mif), dexamethasone (Dex), bicuculline (Bic), and NE into the medial and intermediate NTS.
RESULTS
Microinjection of Dex (0.39 mmol.L-1, 0.1 microL) into the medial and intermediate NTS abolished the vasodepressed response to NE (8 mmol.L-1, 0.1 microL) microinjected into the same area 10 min later, and the inhibition did not disappear until 4 h. The rapid inhibitory effects of Dex on NE vasodepression was not antagonized by Mif (4.66 mumol.L-1, 0.1 microL), but it was blocked by Bic (3.24 mumol.L-1, 0.1 microL).
CONCLUSION
Dex abolished cardiovascular response to NE microinjected into NTS which may be mediated by GABAA receptor.
目的
研究地塞米松对孤束核（NTS）中去甲肾上腺素（NE）诱导的心血管反应的影响。
方法
将米非司酮（Mif）、地塞米松（Dex）、荷包牡丹碱（Bic）和NE注射到内侧和中间NTS后，观察这些药物引起的心血管作用变化。
结果
向内侧和中间NTS微量注射Dex（0.39 mmol.L-1，0.1 μL）可消除10分钟后向同一区域微量注射NE（8 mmol.L-1，0.1 μL）所引起的血管抑制反应，且该抑制作用直到4小时才消失。Dex对NE血管抑制的快速抑制作用未被Mif（4.66 μmol.L-1，0.1 μL）拮抗，但被Bic（3.24 μmol.L-1，0.1 μL）阻断。
结论
Dex消除了向NTS微量注射NE所引起的心血管反应，这可能由GABAA受体介导。
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