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中药贞玄饮对改善脑缺血大鼠脑血流量作用的观察

Observation on the effects of Chinese medicine zhenxuanyin for improving cerebral blood flow in rats with cerebral ischemia.

作者信息

Jingyi W, Yasuhiro M, Naoya H, Seok R C, Yoshiharu Y, Nagara T, Fumiko T, Shigeru M, Junji K

机构信息

Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.

出版信息

J Tradit Chin Med. 1997 Dec;17(4):299-303.

PMID:10437217
Abstract

Zhenxuanyin [symbol: see text] is composed of pure Chinese medicinal herbs, such as gastrodia tuber, poria cocos, ligusticum wallichii etc. 4-verssel occlusion (4VO) model rats were reperfused after 30 minutes' complete occlusion, and Zhenxuanyin was administered 3 times a day. 24 hours later, 123I-IMP uptake in the brain was evaluated as an index of cerebral blood flow (CBF). The results show that Zhenxuanyin (0.03 g/kg, 0.3 g/kg, 1 g/kg, or 3 g/kg a day) can greatly improve the blood flow in the main cerebral regions, and 0.3 g/kg can increase cerebral blood flow (CBF) to the normal level.

摘要

镇眩饮[符号:见正文]由天麻、茯苓、川芎等纯中药组成。将四血管闭塞(4VO)模型大鼠完全闭塞30分钟后再灌注,镇眩饮每日给药3次。24小时后,以脑摄取123I-IMP作为脑血流量(CBF)的指标进行评估。结果表明,镇眩饮(每日0.03 g/kg、0.3 g/kg、1 g/kg或3 g/kg)可显著改善大脑主要区域的血流,0.3 g/kg可使脑血流量(CBF)增加至正常水平。

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