Muić V, Ljubicić M, Vodopija I
Croatian National Institute of Public Health, Croatia.
Acta Med Croatica. 1999;53(1):19-22.
Changes in the proportion of VDRL nonreactors among the people who had come into contact with Treponema pallidum in the course of their lifetime were assessed within the frame of the Diagnostic Proficiency Program covering serologic laboratories for the detection of syphilis in Croatia. Based on the analysis of the CNIPH serologic laboratory records the paper shows a clear increase in the above share over the past 22 years. Data on 491 infected persons (those reactive to the reference TPHA test), mean age 52.87 years, were analyzed. During 22 years of observation (1976-1998), this proportion rose from 21.92% (1976-1979) through 51.79% (1980-1989) to 64.86% (1990-1998). At the same time, this tendency reveals a considerable decrease in the number of infected persons exhibiting VDRL reaction (i.e. with potentially active late syphilis), which could be ascribed to the ever more effective detection of the infected and to their ever earlier and more efficient treatment.
在克罗地亚梅毒检测血清学实验室诊断能力提升计划框架内，评估了一生中接触过梅毒螺旋体的人群中梅毒血清试验（VDRL）无反应者比例的变化。基于克罗地亚国家公共卫生研究所血清学实验室记录分析，本文显示过去22年中上述比例明显上升。对491名感染者（梅毒螺旋体血细胞凝集试验[TPHA]呈阳性）的数据进行了分析，这些感染者平均年龄为52.87岁。在22年观察期（1976 - 1998年）内，这一比例从1976 - 1979年的21.92%，升至1980 - 1989年的51.79%，再到1990 - 1998年的64.86%。与此同时，这一趋势表明梅毒血清试验（VDRL）呈反应性（即可能患有活动性晚期梅毒）的感染者数量显著减少，这可能归因于对感染者的检测日益有效以及对他们的治疗越来越早且有效。
