Sefer S, Ivanusa M, Kes P, Ratković-Gusić I, Vasilj D
KB Sestre milosrdnice, Klinika za unutarnje bolesti, Zavod za nefrologiju i dijalizu, Zagreb.
Lijec Vjesn. 1999 Apr-May;121(4-5):126-8.
We report the case of a 57-year-old man treated with interrupted rifampicin therapy for urinary tract tuberculosis who experienced acute renal failure, intravascular hemolysis and toxic hepatitis. This combined adverse reactions are rare. Supportive treatment with dialysis and withdrawal of rifampicin result with complete recovery. Interrupted and intermittent therapy with rifampicin should be avoided and noncompliant patients should be given alternative treatment when possible.
我们报告了一例57岁男性患者，其因尿路结核接受间断性利福平治疗，出现了急性肾衰竭、血管内溶血和中毒性肝炎。这种联合不良反应较为罕见。通过透析进行支持治疗并停用利福平后患者完全康复。应避免使用间断性和间歇性利福平治疗，对于不依从的患者，应尽可能给予替代治疗。
